hyperhidrosis

What Role Do Genetics Play in Hyperhidrosis, and Is There a Hereditary Pattern in the Occurrence of Excessive Sweating?

Shad Douglas

07 Aug 2025 — 2 min read

Summary

Genetics play a significant role in hyperhidrosis, with evidence suggesting a hereditary pattern, particularly for primary focal hyperhidrosis. This condition often runs in families, and research indicates a strong genetic predisposition for its occurrence.

Genetic Influence on Hyperhidrosis

Hyperhidrosis refers to a condition characterized by excessive sweating beyond what is required for thermoregulation. There are two types of hyperhidrosis: primary focal hyperhidrosis and secondary generalized hyperhidrosis. Primary focal hyperhidrosis usually affects specific areas, such as the palms, soles, underarms, and face, whereas secondary hyperhidrosis is often a result of another medical condition or medication, affecting larger or multiple areas of the body.

Hereditary Patterns in Primary Focal Hyperhidrosis

Primary focal hyperhidrosis shows a strong hereditary component. Studies have revealed that about 30% to 50% of individuals with primary hyperhidrosis have a family history of the disorder [Hoorens & Ongenae, 2012]. This suggests an autosomal dominant inheritance pattern, meaning that if one parent carries the gene, there is a 50% chance of passing it on to offspring.

Genetic linkage studies have further supported the hereditary nature of this condition, although the exact genes involved are still being researched. Recent advances in genetics have started to identify specific gene mutations that might contribute to hyperhidrosis, but more research is required to establish concrete genetic markers [Khan et al., 2019].

Non-Genetic Factors and Secondary Hyperhidrosis

Secondary hyperhidrosis, on the other hand, is not typically linked to genetic factors. It is most commonly associated with conditions such as hyperthyroidism, diabetes, menopause, and the use of certain medications. Therefore, addressing the underlying condition often alleviates the excessive sweating [American Academy of Dermatology Association, 2023].

Examples and Implications

For instance, if an individual with hyperhidrosis has a parent or sibling affected by the same condition, it increases the likelihood that their hyperhidrosis is genetically influenced. This familial trend can be used in clinical settings to help differentiate between primary and secondary types of hyperhidrosis, guiding treatment options.

Conclusion

While genetics play a pivotal role in the occurrence of primary focal hyperhidrosis, ongoing research is essential to fully understand the genetic mechanisms at play. In contrast, secondary hyperhidrosis is primarily influenced by non-genetic factors related to other health conditions.

References

[Hoorens & Ongenae, 2012] Hoorens, I., & Ongenae, K. (2012). "Primary focal hyperhidrosis: current treatment options and a step-by-step treatment algorithm." Journal of the European Academy of Dermatology and Venereology.
[Khan et al., 2019] Khan, S. et al. (2019). "Genetic Basis of Hyperhidrosis: An Update." Frontiers in Genetics.
[American Academy of Dermatology Association, 2023] American Academy of Dermatology Association. (2023). "Excessive sweating: Overview."

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