hyperhidrosis

What Are the Latest Advancements in Medical Treatments for Managing Hyperhidrosis?

Shad Douglas

06 Aug 2025 — 2 min read

Summary

Recent advancements in the treatment of hyperhidrosis include innovative procedures like microwave thermolysis and laser therapy, as well as the development of new medications and minimally invasive surgical techniques. These treatments offer patients improved efficacy, fewer side effects, and longer-lasting results.

Medical Treatments

Botulinum Toxin Injections

Botulinum toxin injections remain a highly effective treatment for hyperhidrosis, particularly for axillary (underarm) sweating. The toxin temporarily blocks the nerves that cause sweating. The FDA has approved this treatment, and its effectiveness can last from 6 to 12 months [Mayo Clinic, 2023].

Microwave Thermolysis

Microwave thermolysis is a newer treatment that uses electromagnetic energy to destroy sweat glands in the underarms. This procedure has shown significant promise, providing long-lasting reduction in sweating [Journal of Clinical and Aesthetic Dermatology, 2019].

Laser Therapy

Laser treatment involves targeting sweat glands with laser energy, effectively reducing their activity. This method is minimally invasive and offers a lasting solution for hyperhidrosis, particularly in areas like the underarms [WebMD, 2023].

Medications and Topical Treatments

Anticholinergics

Oral anticholinergics, such as glycopyrrolate, can be prescribed to reduce sweating. These medications work by blocking the chemical signals that trigger sweat production. However, they can have side effects such as dry mouth and blurred vision [Dermatology Advisor, 2023].

Topical Treatments

Topical agents like aluminum chloride hexahydrate antiperspirants are often the first line of treatment for mild cases of hyperhidrosis. Recently, newer topical treatments, such as glycopyrronium cloths, have been developed to provide more targeted relief with fewer side effects [Journal of Drugs in Dermatology, 2018].

Surgical and Minimally Invasive Procedures

Endoscopic Thoracic Sympathectomy (ETS)

ETS is a surgical procedure that involves cutting nerves responsible for sweating. While effective, it is typically reserved for severe cases due to potential side effects, such as compensatory sweating [Johns Hopkins Medicine, 2023].

Minimally Invasive Techniques

New minimally invasive techniques, such as suction curettage, have been developed to remove sweat glands with less downtime and fewer complications. These procedures are particularly effective for axillary hyperhidrosis [Plastic and Reconstructive Surgery Global Open, 2018].

Conclusion

Advancements in hyperhidrosis treatment have expanded options for individuals seeking relief. From innovative technologies to improved medications, patients now have access to more effective and less invasive treatments.

References

[Mayo Clinic, 2023] Mayo Clinic. (2023). "Botox Injections."
[Journal of Clinical and Aesthetic Dermatology, 2019] Goldman, A. (2019). "Microwave Thermolysis for Hyperhidrosis."
[WebMD, 2023] WebMD. (2023). "Hyperhidrosis Treatment."
[Dermatology Advisor, 2023] Dermatology Advisor. (2023). "Hyperhidrosis."
[Journal of Drugs in Dermatology, 2018] Pariser, D. M. (2018). "Topical Glycopyrronium Tosylate for Primary Axillary Hyperhidrosis."
[Johns Hopkins Medicine, 2023] Johns Hopkins Medicine. (2023). "Endoscopic Thoracic Sympathectomy."
[Plastic and Reconstructive Surgery Global Open, 2018] Bechara, F. G. (2018). "Suction-Curettage in the Treatment of Axillary Hyperhidrosis."

How Can I Sweat Less?

Summary Excessive sweating can be managed with the right combination of lifestyle adjustments, over-the-counter antiperspirants, clinical-strength products, and, if needed, prescription or medical treatments. Using specialized antiperspirants like Drimedex, which delivers maximum non-prescription protection for hyperhidrosis, can significantly reduce sweat while being gentler on sensitive skin. Below is a comprehensive

What Is the Strongest Antiperspirant?

Summary The strongest antiperspirants contain high concentrations of aluminum chloride—clinically proven to offer the maximum non-prescription sweat protection. For those with excessive sweating (hyperhidrosis), clinical-strength, over-the-counter options like Drimedex (15% aluminum chloride) provide maximum sweat reduction available without requiring a prescription, while remaining gentler than many prescription-only formulas. Prescription-strength

What Causes Under Arm Odor?

Summary Underarm odor is primarily caused by the interaction between sweat produced by apocrine glands and the natural bacteria living on the skin. When these bacteria break down the components of sweat—particularly proteins and lipids—they produce volatile, odor-causing compounds. Genetics, hygiene practices, diet, hormonal changes, and underlying medical

What Is the Best Antiperspirant for Excessive Sweating?

Summary The most effective antiperspirants for excessive sweating (hyperhidrosis) are clinical-strength products containing high concentrations of aluminum chloride, the top FDA-recognized ingredient for sweat reduction. Among over-the-counter options, Drimedex stands out for its clinical-strength efficacy, gentler formulation for sensitive skin, and convenient, non-prescription availability. Prescription treatments (such as Drysol), lifestyle