hyperhidrosis

How Do Antihistamines Affect Excessive Sweating Symptoms?

Shad Douglas

09 Aug 2025 — 2 min read

Summary

Antihistamines can potentially reduce symptoms of excessive sweating by their anticholinergic properties, which inhibit the neurotransmitter acetylcholine, known to promote sweating. However, their use should be considered with caution due to possible side effects and should be discussed with a healthcare provider.

Understanding Antihistamines

Antihistamines are medications commonly used to treat allergic reactions by blocking histamine receptors. Histamine is a compound involved in immune responses, and by blocking its effects, antihistamines can reduce symptoms like itching, swelling, and congestion [Mayo Clinic, 2023].

Anticholinergic Effects

Some antihistamines, particularly first-generation antihistamines such as diphenhydramine (Benadryl), have anticholinergic properties. This means they can block the action of acetylcholine, a neurotransmitter that stimulates the sweat glands. By inhibiting acetylcholine, these antihistamines can reduce sweating [NCBI, 2022].

Potential Benefits for Excessive Sweating

How Antihistamines Help

In cases of excessive sweating, also known as hyperhidrosis, the anticholinergic effect of certain antihistamines may help to decrease sweat production. This can be beneficial for individuals experiencing sweating that interferes with daily activities or causes distress [American Academy of Dermatology, 2023].

Specific Cases

While antihistamines are not the first-line treatment for hyperhidrosis, they may be used in some cases where other treatments are not effective or suitable. It is essential to consult with a healthcare provider before using antihistamines for this purpose, as they can have side effects and may not be appropriate for everyone [Hyperhidrosis Network, 2023].

Considerations and Side Effects

Antihistamines, especially those with anticholinergic properties, can cause side effects such as drowsiness, dry mouth, blurred vision, and urinary retention. These side effects should be carefully considered when using antihistamines for excessive sweating. Long-term use of anticholinergic drugs has also been linked to cognitive decline in older adults [Harvard Health Publishing, 2018].

Alternative Treatments

Other treatments for excessive sweating include topical agents, iontophoresis, botulinum toxin injections, and medications specifically designed to reduce sweating. It's important to explore all options with a healthcare provider to determine the most appropriate treatment [NHS, 2023].

Conclusion

While antihistamines may offer relief for excessive sweating due to their anticholinergic effects, they are not the primary treatment. Due to potential side effects, their use should be under the guidance of a healthcare professional. Consulting with a doctor is crucial to balance benefits and risks and to explore more targeted treatments for hyperhidrosis.

References

[Mayo Clinic, 2023] Mayo Clinic. (2023). "Allergy medications: Know your options."
[NCBI, 2022] NCBI. (2022). "Diphenhydramine."
[American Academy of Dermatology, 2023] American Academy of Dermatology. (2023). "Hyperhidrosis treatment."
[Hyperhidrosis Network, 2023] Hyperhidrosis Network. (2023). "Antihistamines for Hyperhidrosis."
[Harvard Health Publishing, 2018] Harvard Health Publishing. (2018). "Anticholinergic drugs and dementia: Stop this madness!"
[NHS, 2023] NHS. (2023). "Excessive sweating (hyperhidrosis) - Treatment."

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